Artificial Oocyte Activation (AOA)
A laboratory technique that helps eggs fertilise normally when previous cycles had low fertilisation.
- Rescues low-fertilisation cycles
- Used in carefully selected cases
- Paired with ICSI
About this treatment
Sometimes, even after ICSI, eggs fail to fertilise as they should. Artificial Oocyte Activation (AOA) is a specialised lab technique that gives the egg the chemical 'activation' signal it needs to begin developing into an embryo.
We use AOA in carefully selected cases — typically where a previous cycle had a very low fertilisation rate — to materially improve the chance that injected eggs go on to fertilise and form healthy embryos.
Who it's for
- Total or very low fertilisation in a previous ICSI cycle
- A suspected egg-activation deficiency
- Severe male-factor cases after ICSI
Key benefits
- Can markedly improve fertilisation rates
- Helps couples after a failed-fertilisation cycle
- Targeted, evidence-based use
Every treatment plan at Shobha IVF is personalised. The details here are a guide — your specialist will tailor each step to your unique situation.
Oocyte Activation (AOA) — your questions
Common questions about this treatment. Anything else? Our team is happy to talk it through.
Mainly when a previous ICSI cycle resulted in very low or zero fertilisation despite good eggs and sperm — a sign the egg may not be activating normally.
It's used selectively and only where clinically indicated. Your specialist will discuss whether it's appropriate for your situation.
Related treatments
All treatments
The information on this page is general and educational, and is not a substitute for professional medical advice, diagnosis or treatment. Fertility outcomes vary from person to person and depend on age, diagnosis and other individual factors; no result is guaranteed. Any success figure shown is a beta-hCG positive (pregnancy-test) rate per embryo transfer at our Solapur centre, which is not a live-birth rate. Please consult our specialists for advice specific to you.